Journal: Scientific Reports
Article Title: Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
doi: 10.1038/s41598-021-02289-w
Figure Lengend Snippet: ECoG and striatal LFP. ( a ) Visualization of electrode placement on the skull. Grid 1 mm. ( b , c ) Visualization of eM (AP + 1; ML − 1) and eCP (AP − 0.5; ML + 2.5) electrode placements on sagittal slice 1.44 mm lateral to bregma (modified from Paxinos and Franklin the Mouse Brain in Stereotaxic Coordinates, 2001). ( d ) Power spectral density of motor cortex (eM) electrocorticogram. ( e ) Power spectral density of local field potentials in the striatum (eCP). X-axis—signal frequency in Hz; Y-axis—power spectral density in % of total density. Teal and black lines—power spectra of TAAR5-KO and WT mice, respectively; dotted lines—standard error of the mean (SEM). **P < 0.01; ****P < 0.0001 two-way ANOVA of the whole 0.9–20 Hz range. Filled grey area—significant differences in Sidak’s multiple comparisons post hoc test. eM (circle with red outline) epidural screw above motor cortex, eCP (filled red circle) intracerebral electrode in caudate-putamen, ref reference electrode (epidural screw), ACB nucleus accumbens, CP caudate-putamen, CTX cortex, GP globus pallidus, HY hypothalamus, LSX Lateral septal complex, MCTX motor cortex, Pal pallidum, TH thalamus.
Article Snippet: Two types of electrodes were used, epidural screws for electrocorticogram (ECoG) recordings (0.5 mm in diameter; 1 mm in length; steel) and intracerebral electrodes for local field potential (LFP) recordings [50 μm in diameter; 1.2 mm/3.2 mm in length; tungsten wire in perfluoroalkoxy polymer isolation (795500, A-M Systems)].
Techniques: Modification